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Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. 2013 Mar; 62(3):335-6. 2022; 17(9):e0274219. J Clin Invest. 2009 Jul; 50(1):185-97. Clin Gastroenterol Hepatol. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. 2011 Jan 04; 108(1):308-13. 2021 01; 335:113496. Am J Physiol Cell Physiol. 2013 Jul; 145(1):16-31. Introducing PNAS Nexus. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Blood. 1990 Nov; 26(11):1011-23. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. 2019 07 23; 116(30):15184-15193. 2000 Apr 21; 275(16):12207-13. 2019 07; 70(1):127-141. J Gastroenterol Hepatol. J Exp Med. 2016 08; 65(2):369-76. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 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Am J Gastroenterol. 1997 May; 25(5):1128-35. 2019 01; 17(2):218-230. Gastroenterology. We lose people all of the time. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. J Hepatol. J Hepatol. 2012 Apr; 56(4):965-72. J Clin Invest. Transient induction of c-jun during hepatic regeneration. Luedde T, Rodriguez ME, Tacke F, Xiong Y. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER J Cell Biol. J Hepatol. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. J Clin Invest. 1991 Oct; 14(4 Pt 1):740-2. PLoS One. 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Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. J Hepatol. 2008 Mar; 23 Suppl 1:S98-103. 2011 May; 53(5):1433-5. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. 2016 Aug; 38(4):291-302. 2020 Apr; 4(4):606-626. Hepatology. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Role of Gut Microbiota in Liver Disease. Alcohol Clin Exp Res. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. 1999 Apr 15; 162(8):4447-54. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. J Biol Chem. 2007 Aug; 47(2):307-9. 2011 Jul; 179(1):189-98. J Exp Med. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Integr Biol (Camb). 2014 Jul 21; 5:4451. What's new in liver fibrosis? Circulation. Int J Biochem Cell Biol. 2015 Jul; 22(7):512-8. Gastroenterology. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. 1991 Jun; 87(6):2230-5. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Cell Host Microbe. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Hepatology. Clin Gastroenterol Hepatol. Nucleic Acids Res. 1999; 66:205-22. Pharm Res. MELD and the practicing gastroenterologist. Brain Commun. 1994 Dec 09; 269(49):30789-97. Hepatology. Hepatology. NEK1 mutations in familial amyotrophic lateral sclerosis. Interactions between the intestinal microbiome and liver diseases. PLoS One. Aging Ment Health. J Gastroenterol Hepatol. Hepatology. 2008 Jun; 118(6):2121-31. 1993 Jan; 264(1 Pt 1):G95-103. 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Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. J Biol Chem. Surgery. Gastroenterology. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Proc Natl Acad Sci U S A. PLoS One. 2022 Mar; 1(1):pgac006. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Am J Physiol Gastrointest Liver Physiol. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 2011 Jun; 31(3):521-32. Hepatology. Am J Physiol Gastrointest Liver Physiol. Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D. 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